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iloperidone increases levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Iloperidone can be a time-dependent CYP3A inhibitor and should bring on amplified plasma amounts of drugs predominantly removed by CYP3A4.Numerous plausible but uninvestigated web pages of action for modafinil, both intracellular a